The γδ TCR structure already suggests that individual γ and δ germline sequences may have become adapted for specific antigens, as for receptors in the innate immune system.

All γδ T cells express a somatically rearranged T cell receptor (TCR) through which they recognize antigen. These γδ TCRs are composed of a γ- and δ-chain, with a structure generally similar ...

GDT-002 is a potential first-in-class cellular immunotherapy UTRECHT, Netherlands and BOSTON, July 6, 2021 /PRNewswire/ -- Gadeta B.V., a clinical ...

Immunocore and Gadeta Announce Agreement to Develop First Gamma Delta (γδ) TCR ImmTAC for Solid Tumors. Gamma delta TCRs offer potential to address large number of patients without HLA ...

Manufacturing-Driven TCR Reprogramming: All analyzed clinical batches showed a clear and consistent shift from αβ-TCR to γδ-TCR dominance, with enrichment of Vγ9 clones.

Eureka Therapeutics Announces Publication of Crystal Structure of TCR Mimic Redirected T Cells ... and co-expressed a co-stimulatory molecule to create its proprietary ARTEMIS® T cell receptor.