High point totals mean opportunity, and several key matchups stand out as potential fantasy goldmines in Week 10. Week 10 of the NFL season is already upon us, and the challenge of setting lineups and finding an edge in fantasy football only becomes greater than the week before.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime, only for the 49ers to win on a field goal and subsequent fourth-down stop in the final minutes.

The 49ers improved to 6-3 with a Week 9 win over the Giants. See how San Francisco's NFC playoff picture and seeding shape up heading into Week 10.

The 49ers haven't had Brock Purdy since Week 4, and amid reports of his potential return Sunday against the Rams, coach Kyle Shanahan said Purdy may be dealing with the injury the rest of the year.

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.

The San Francisco 49ers got back to winning ways on Sunday, and it was thanks in large part to another strong performance from star running back Christian McCaffrey. The Niners were on the road at MetLife Stadium for Week 9. They took down the New York Giants, 34-24, to improve to 6-3 on the season.

Matthew Stafford thrived once again for the Rams while the 49ers were ruthlessly efficient in Week 9 wins.

Williams, the Niners’ first-round pick (No. 11) in April, was injured late in the fourth quarter of Sunday’s win over the New York Giants at MetLife Stadium, with San Francisco leading by 17. Coach Kyle Shanahan said after the game that the team feared Williams had torn his ACL. Testing on Monday confirmed the diagnosis, the source said.

The San Francisco 49ers needed a win over the New York Giants in Week 9, and they came up with a strong outing in a victory. Here are the highlights.