Oncotarget recently published "Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis" by Kim, et al. which reported that the authors show that CADD522 inhibits ...

The finding, described as the first to test possible medical uses of so-called ATP-synthase inhibitors, may lead to new and more effective anti-cancer medications, according to a new report.

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

The commonly observed symmetry is broken by the accommodation of a single subunit at the dimer interface that anchors an inhibitor. In addition, the ATP synthase has an unusual U-shape arrangement ...

PHILADELPHIA — A novel aldosterone synthase inhibitor, BI 690517, was well-tolerated and reduced urine albumin-to-creatinine ratio in patients with chronic kidney disease, according to a ...

The novel selective aldosterone synthase inhibitor BI 690517 (up to 10 mg daily) with concurrent renin-angiotensin-system (RAS) inhibition, with or without the SGLT2 inhibitor empagliflozin, dose ...

PHILADELPHIA—A novel selective aldosterone synthase (AS) inhibitor, BI690517, may improve the therapeutic ability to slow chronic kidney disease (CKD) progression, an investigator reported at ...