We are interested in whether BACE1 may pick up particular aspects of the AD pathology which are not reflected by already well-investigated marker candidates such as p-tau and Aβ in CSF (reviewed in ...

In AD patients, we propose the existence of highly expressed α2,6-sialylation catalyzed by ST6Gal-I. This ST6Gal-I-mediated α2,6-sialylation of BACE1 regulates BACE1 expression by affecting ...

Researchers created mouse strains expressing human BACE1 years ago (see Bodendorf et al., 2002; Lee et al., 2005; and research models database on hBACE54 and hBACE). However, these mice express high ...

Researchers working at Lerner Research Institute, Cleveland Clinic reported in the November 8, 2021, issue of Nature Cancer that an inhibitor of the beta-amyloid producing enzyme, BACE1, could ...

The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the ...

The study also demonstrated that deletion of ST6Gal-I in rats reduced BACE1 levels and alleviated learning and memory impairments induced by scopolamine, a pharmacological tool used to study AD ...

Traumatic brain injuries have long affected military service members, with the Department of Defense reporting nearly 516,000 cases worldwide from 2000 to 2024.

Alzheimer's plaques reduced by targeting sugar attachment to the BACE1 enzyme Date: January 15, 2015 Source: RIKEN Summary: Hallmark symptoms of Alzheimer's disease can be reduced when sugars are ...