Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver ...

The Liver-Chip predicted the human toxicity that was missed in the animal studies. Liver-Chip Results: Drugs Halted in Previous Clinical Trials Based on Animal Studies ...

The liver chip is designed to catch bad drug reactions that animal tests might miss. For instance, bosentan, a high blood pressure drug, doesn’t harm rats’ livers, but causes bile salts to ...

The company specializes in liver toxicology, metabolic diseases (e.g., T1 & T2 diabetes and NAFLD & NASH liver disease), and oncology (with a focus on immuno-oncology and PDX models).

Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases.The mutations affect multiple organs including the liver where ...