This image shows the structure of an antibody (Y-shaped) and how it binds to different types of antigens (color-coded shapes at the top). The antibody's binding sites, located at the ends of its arms, ...

Human mAbs are currently developed via one of three platforms: transgenic animals that express human immunoglobulins, bacteriophage display of human antigen-binding fragments, and yeast display of ...

These are perfect for diagnostic imaging and intracellular targeting. Fragment Antigen-Binding (Fab) Fragments: These fragments have the antigen-binding regions sans the Fc region, thus reducing ...

A new anti-HER2 IgE antibody potentially offers new therapy options for treatment-resistant breast and ovarian cancers.

A recent study provides insight into how antigen binding primes T cells to be at the forefront of the immune response. The research team hypothesized that binding of the antigen to the T-cell receptor ...

Once in the ER, the peptide antigens bind to activated MHC class I molecules (3), which subsequently transport the complexes through the Golgi toward the cell surface (4). This pathway generates ...

The immune system responds to an infection by producing antibodies that recognize and bind to the cell surface of the pathogen, thus marking it as an intruder and triggering an immune response. For ...

Peptide binding to MHC I. CTLs are generally activated by antigens that are derived from intracellular proteins, which are presented in a complex with MHC I on the surface of cells. Intracellular ...

CERo’s technology works by grafting onto patients’ own T-cells a receptor that binds to a naturally occurring human antigen ...