Massive proteomics database links gene variant APOE 4 to chronic inflammation.

This suggested to them that, regardless of disease state, ApoE expression in a neuron was tied to that of immune genes. They did not find this relationship in non-neuronal cell types, including ...

ApoE’s Potential Roles. Without astrocytic ApoE, fewer synapses mature (top). Without plasma ApoE (bottom right), the blood-brain barrier may leak and toxins could enter the brain. [Courtesy of ...

The ApoE gene may have a more influential role than first thought; ... Beta-amyloid is a sticky protein that clumps together, blocking neuron-to-neuron signaling in Alzheimer’s patients.

ApoE is an ideal target for halting progression of Alzheimer's disease ... In the latest issue of the journal Neuron, available today online, Gladstone Investigators Robert Mahley, MD ...

ApoE has long been a focus of Alzheimer's disease research because people carrying a gene that ... apoE might help determine which neuron should be recognized and cleared by the immune system ...

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron , 2017; 96 (5): 1013 DOI: 10.1016/j.neuron.2017.11.014 Cite This Page : ...

A study led by scientists at the University of Science and Technology of China (USTC) in Hefei City is the first to show that astrocytic apolipoprotein E (ApoE) regulates neuronal epigenetic states ...

As a first step, his team is testing whether it’s possible to stop or slow tau-driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents.

Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids – which are building blocks of ...

The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4.