Massive proteomics database links gene variant APOE 4 to chronic inflammation.

The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4. While APOE4 increases the ...

New research offers clues into how APOE isoforms affect microglia function differently in Alzheimer's disease, leading to strikingly different risk profiles.

Alzheimer’s disease may be inherited more often than previously known, according to a new study that paints a clearer picture of a gene long known to be linked to the common form of dementia.

If you have two copies of the APOE4 gene, new research suggests that you’re very likely to develop Alzheimer’s. Experts break down the findings and share what you can do to lower your risk.

The APOE-R136S mutation protects against APOE4-driven AD pathologies, providing a target for therapeutic development against AD.

Alzheimer's disease (AD) is a debilitating neurodegenerative condition that affects a significant proportion of older people worldwide. Synapses are points of communication between neural cells that ...

New research in mice suggests that removing the APOE4 gene dramatically reduces the incidence of Alzheimer’s disease.

Study finds that a form of APOE, a protein linked to Alzheimer’s, degrades cartilage. The findings could shed light on the cause of osteoarthritis.

The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4.