Massive proteomics database links gene variant APOE 4 to chronic inflammation.

In this study, researchers looked at APOE in microglia, the brain's immune cells known to play a role in Alzheimer's disease. As the three versions of APOE are evolutionarily unique to humans ...

Alzheimer’s disease may be inherited more often than previously known, according to a new study that paints a clearer picture of a gene long known to be linked to the common form of dementia.

“Recently, a rare APOE variant, APOE3-R136S (Christchurch), was found to protect against early-onset AD in a PSEN1-E280A carrier. In this study, we sought to determine if the R136S mutation also ...

To determine how the E4 variant of the APOE gene impacts Alzheimer’s disease, Koutsodendris et al. were tasked with creating a line of mice that contained the human APOE gene.

If you have two copies of the APOE4 gene, new research suggests that you’re very likely to develop Alzheimer’s. Experts break down the findings and share what you can do to lower your risk.

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease.The study, led by Dr Sarah Marzi and Dr ...

Exactly how this gene variant influences Alzheimer’s risk is the subject of much research, including the find that proteins produced by APOE4 tend to break down into fragments in neurons ...

Study finds that a form of APOE, a protein linked to Alzheimer’s, degrades cartilage. The findings could shed light on the cause of osteoarthritis. Skip to Main Content. HHS. CDC.

Get Instant Summarized Text (Gist) APOE isoforms distinctly influence microglial function in Alzheimer's disease. APOE4 microglia exhibit increased cytokine production, reduced migration, impaired ...

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr Sarah Marzi and ...