Autophagy has previously been thought to act as a mechanism that fuels early tumorigenesis by recycling other cells to provide nutrients for the replicating cancer cells.

Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively. It is now clear that these processes often occur sequentially ...

A University of Colorado Cancer Center study published today in the journal Developmental Cell pinpoints a molecule that links autophagy and apoptosis, namely a transcription factor called FOXO3a.

Defects in the normal cell autophagic process lead to cancer in animal models, and anticancer treatments stimulate autophagy instead of apoptosis in various cancer cell lines.

Opening an autophagy window as the apoptosis door starts to close Date: September 24, 2020 Source: Tokyo Medical and Dental University Summary: Researchers have successfully attached the cancer ...

WIKIMEDIA, NATIONAL INSTITUTES OF HEALTH Cancer cells in the throes of death, being ripped apart from the inside by apoptosis, can evidently survive and piece themselves back together. A study ...

A recent study published in Genes & Diseases reveals a novel role of XPR1 in promoting ovarian cancer growth by regulating ...

Endoplasmic reticulum (ER) stress-induced apoptosis plays a crucial role in various liver diseases. Hepatocytes respond to ER stress by activating the unfolded protein response and autophagy, which is ...

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its potential as a therapeutic target and the challenges of tipping the ...

In addition, in this setting autophagy plays a role in guarding against the start of cancer and is related to the aging process.