Autophagy, a natural cellular process, recycles damaged components, boosting health and anti-aging benefits. Fasting, ...

In a previous study published in Autophagy, researchers from Doshisha University, Japan, revealed that PARK7/DJ-1—a PD-associated protein renowned for its antioxidative function and ...

Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons. Nature Aging , 2024; DOI: 10.1038/s43587-023-00548-1 ...

In a previous study published in Autophagy, researchers from Doshisha University, Japan, revealed that PARK7/DJ-1-a PD-associated protein renowned for its antioxidative function and mitochondrial ...

This work is published in Nature Aging, in the paper, “Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans ...

The accumulation of this protein suggests that autophagy wasn’t working properly. Elevated p62 levels were seen alongside a rise in caspase-3, ...

VMP1, a protein involved in both autophagy and ER-phagy (removal of damaged ER), is downregulated in pancreatitis. TFEB, a master regulator of lysosomal biogenesis and autophagy, is also decreased.

Of 32 dementia-related proteins, these 15 are undergoing further study. The image includes descriptions of their primary molecular functions. [Courtesy of Walker et al., Science Translational Medicine ...

“We also studied the mechanism by which Beclin-1 regulates uterine development,” Kommagani said. “Beclin-1 is known to regulate two distinct natural processes called autophagy and apoptosis that help ...

PARK7, a protein linked to Parkinson’s disease, is secreted from cells via an unconventional pathway involving both macroautophagy and chaperone-mediated autophagy (CMA) under oxidative stress.

Proteins are conventionally trafficked and secreted extracellularly via the endoplasmic reticulum-Golgi pathway. Some proteins that bypass this system and use unconventional mechanisms to exit the ...