B cells play a vital role in the immune system, given their key function in antibody production. Antibodies, also known as immunoglobulins, are glycosylated protein molecules that appear on the ...

Antibodies are Y-shaped protective proteins manufactured by B lymphocytes in reaction to invading pathogens. When B lymphocytes encounter foreign antigens expressed by antigen-presenting cells (e ...

T-bet is a transcription factor, one of the control proteins in the cell nucleus that can turn specific groups of genes on ...

Single-B cell technology, when applied to antibody discovery, however, is both high-throughput and can allow the identification of antibodies with paired light and heavy chains in 1-2 weeks.

Antibody-secreting B cells need to produce a lot of energy to churn out antibody production, and they also must turn on processes that protect the cells from some of the detrimental side effects ...

At the surface, the immune response to a flu virus is simple. Some cells recognize the pathogen and send a signal to the ...

One of the key early milestones in the history of antibody engineering was the development of hybridoma technology in 1975 by César Milstein and Georges Köhler. This allowed for the production of ...

The study highlights T-bet's importance in memory B cells, essential for rapid antibody production and sustained immune ...

Increasing evidence supports a role for B cells and antibodies in the pathogenesis of multiple sclerosis (MS). Here, Meinl and colleagues discuss the proinflammatory contribution of B-cell ...

Intestinal microbes trigger expansion of these B cell populations and antibody production, but until now it was unknown whether this was a random process, ...

Antibody-secreting B cells need to produce a lot of energy to churn out antibody production, and they also must turn on processes that protect the cells from some of the detrimental side effects of ...