The aberrant activation of B cells plays a central ... potent and selective inhibitor of the B-cell receptor (BCR) signalling molecule Bruton's tyrosine kinase (BTK), which shows promising ...

Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12, 541–552 (2003 ... S1097-2765(03)00350-2. Jones, R. B. et al. A quantitative protein interaction network for ...

Stimulating a receptor in adipocytes enhanced energy expenditure and caused sustained weight loss in mice, offering targets ...

In a nutshell Scientists discovered a new type of fat cell precursor (CP-A) that appears specifically during middle age, ...

ADCs in Preclinical Development for the Treatment of B-cell Malignancies With the evolving ... process of ADC internalization and prodrug activation, will be of considerable interest.

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...