Bruton's tyrosine kinase (BTK) is important in B cell receptor (BCR) signalling, and so BTK is altered in many types of B cell-derived malignancy. This Review discusses the molecular biology of ...

Second- and third-generation BTK inhibitors, including non-covalent options, offer additional lines of defense by targeting the same pathway with different mechanisms or improved safety profiles.

Degrader outmaneuvers cancer target BTK NX-2127 can halt a signaling pathway in cancer development, even when a key enzyme mutates by Bethany Halford February 1, 2024 ...

It has been previously demonstrated that the Bruton tyrosine kinase (BTK) pathway plays a key role promoting cell adhesion and chemotaxis, and that increased adhesion and aberrant chemotaxis ...

Publisher's Note. The Understanding the Pathway article by Wiestner, entitled "Targeting B-Cell Receptor Signaling for Anticancer Therapy: The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Induces ...

Novel Inhibitors of the BTK SH2 Domain Selectively and Potently Block BTK Signaling and are Efficacious in Preclinical Models of Chronic Spontaneous Urticaria Poster Number: LB1255 ...

Sunday, January 5, 2025. News & Perspective Drugs & Diseases CME & Education Video Drugs & Diseases CME & Education Video ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

It has been previously demonstrated that the Bruton tyrosine kinase (BTK) pathway plays a key role promoting cell adhesion and chemotaxis, and that increased adhesion and aberrant chemotaxis ...