Multiple strategies have been employed by pathogenic bacteria to sabotage host innate ... The new role of Rag-Ragulator in caspase-8-mediated pyroptosis confirms its key function as a central ...

These results suggested that the mutant bacteria were inducing pyroptosis via non-canonical activation of caspase 11. Indeed, experiments with caspase-deficient macrophages showed that caspase 11 ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Pyroptosis is regulated through caspase-1-dependent and independent mechanisms. Activation of caspase-1, 4, 5, or 11 can form N-terminal fragments, which creates pores.

These results suggest that WD disrupts the epithelial barrier by altering gut bacteria to produce a high concentration of DCA, which induces Gsdme-mediated pyroptosis and disrupts the intestinal ...

In total, 39 differentially expressed pyroptosis genes were identified by comparing normal and tumor samples. Correlation analysis revealed 933 pyroptosis-related lncRNAs. Furthermore, univariate Cox ...

The cell at the top right is dying through caspase-11 dependent pyroptosis, the mechanism West and colleagues identified in this paper. It's mitochondria are gone and the nucleus also condensed ...

Pyroptosis components increase the proliferative and migratory abilities of lung cancer cells, but also promote an anti-tumor immune microenvironment," remarks Dr. Zhou.