Altogether, this work identifies a new regulator of a key signalling pathway of the innate immune system, and reveals a direct molecular target of caspase-8 in its role in controlling gene expression.

In a regulatory filing, Telomir Pharmaceuticals (TELO) reported new preclinical results evaluating the effects of its lead candidate, Telomir-1, ...

Our lab has pioneered a fluorescence complementation-based technique (Caspase BiFC) that measures one of the first steps in caspase activation. A large focus of our lab is using the caspase probes ...

Caspase proteins play a critical role in programmed cell death, and they can spur the immune system to fight off disease. But humans don't have a single caspase that can fulfill the functions ...

Furthermore, the level of Bax/Bcl2 and caspase 3 pathway were detected by RT-PCR and Western-blot in through transplanting CRC cells into BALB/c nude mice. Results: MTT assay and Trypan blue staining ...

Arsenic trioxide induces apoptosis in MDS cell line MUTZ-1 cells via caspase-dependent pathways and down regulation of hTERT. JCO 23 , 3208-3208 (2005). DOI: 10.1200/jco.2005.23.16_suppl.3208 ...

Anti-Caspase-3 RabMAb Primary Antibodies. One RabMAb primary antibody (ab32499) only detects pro-form of Caspase 3 and does not recognize any cleaved caspases, while the other (ab32042) only ...

Mitochondria play a central role in apoptosis by releasing molecules (such as cytochrome c) that activate the caspase pathways to lead to cell death. Many proteins have been linked to this ...

In addition to regulating lipid biosynthesis and uptake, sterol regulatory element binding protein (SREBP) is involved in mediating biological signaling networks. SREBP is a key transcription factor ...