The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that ...

The cell cycle and its system of checkpoint controls show strong evolutionary conservation. As a result, all eukaryotes — from single-celled yeast to complex multicellular vertebrates — pass ...

Leukemia - Cell Cycle Checkpoints and Cancer. Chapter 6 summarizes the regulation and function of the p53 tumour suppressor, one of the key checkpoint regulators.

If these checkpoints are lost due to mutated proteins, then the cell cycle is no longer controlled and can lead to ungoverned replication, for example, mutations in the TP53 gene lead to many ...

Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans, say researchers at Georgetown University's ...

Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans, say researchers at Georgetown University's ...

The cell cycle is regulated by cyclins, ... Finally, M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint.

This causes increased levels of p53 and cell cycle arrest. These results are contrary to previous dogma, claiming that other ribosome proteins could elicit a similar response to RPL11 and RPL5.

The cell cycle also serves to protect the cell from DNA damage. Thus, cell cycle arrest, in fact, represents a survival mechanism that provides the tumor cell the opportunity to repair its own damaged ...