The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that ...

Leukemia - Cell Cycle Checkpoints and Cancer. Chapter 6 summarizes the regulation and function of the p53 tumour suppressor, one of the key checkpoint regulators.

If these checkpoints are lost due to mutated proteins, then the cell cycle is no longer controlled and can lead to ungoverned replication, for example, mutations in the TP53 gene lead to many ...

Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans, say researchers at Georgetown University's ...

The cell cycle is regulated by cyclins, ... Finally, M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint.

Faulty cell cycle "checkpoints" that fail to respond to DNA damage effectively may contribute to the high incidence of lung cancer in African-Americans, say researchers at Georgetown University's ...

The cell cycle also serves to protect the cell from DNA damage. Thus, cell cycle arrest, in fact, represents a survival mechanism that provides the tumor cell the opportunity to repair its own damaged ...

This causes increased levels of p53 and cell cycle arrest. These results are contrary to previous dogma, claiming that other ribosome proteins could elicit a similar response to RPL11 and RPL5.

All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both ...