Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nature Cell Biology , 2022; 24 (10): 1499 DOI: 10.1038/s41556-022-00997-7 Cite This Page : ...

Unfortunately, it has proven notoriously difficult to design cyclic peptides with high cell-membrane permeability, i.e., cyclic peptides that can easily diffuse through the lipid bilayer that ...

There are two classes of these peptides: cell penetrating peptides and natural host defense peptides, and both have proven useful in many therapeutic areas, including cancer therapy ...

The internalisation of impermeable molecules into cells is a current challenge in drug development, as many water-soluble bioactive molecules cannot cross the cell membrane. To facilitate the cell ...

A research team reports that molecules believed to be much too large to diffuse across the cell membrane can enter with help from a family of membrane proteins (Science 2022, DOI: 10.1126/science ...

Supercomputer predicts cell-membrane permeability of cyclic peptides Date: July 13, 2021 Source: Tokyo Institute of Technology Summary: Scientists have developed a computational method based on ...