Oncogene - Role of mitochondrial membrane permeabilization in apoptosis and cancer. ... It is this release from the mitochondria that appears to be central to most forms of apoptosis.

The mitochondrial pathway of cell death, in which apoptosis proceeds following mitochondrial outer membrane permeabilization, release of cytochrome c, and APAF-1 apoptosome-mediated caspase ...

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Thus, they reflect Bax activity in mitochondria during apoptosis, demonstrating how apoptotic Bcl-2 proteins such as Bax remodel the supramolecular architecture of the MOM shell to further drive ...

Mitochondria are crucial organelles within eukaryotic cells, responsible for generating adenosine triphosphate (ATP) through oxidative phosphorylation. They play a significant role in maintaining ...

Recent research on MCL-1, a critical protein that is an attractive target for cancer drug development, helps explain why some ...

(Memphis, Tenn. – March 18 th, 2024) The life and death of cells are governed by processes that, when disrupted, can lead to cancer. Apoptosis, the process of programmed cell death, is tightly ...

In particular, mitochondrial Ca 2+ plays a dual role: enabling physiological functions like metabolism and ATP synthesis while contributing to pathological processes such as apoptosis and ...

Mitochondrial Membrane Pore Punching Protein’s Role in Apoptosis Characterized. June 5, 2023. Credit: ... Thus, they reflect Bax activity in mitochondria during apoptosis, ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca 2+ signaling. In particular ...