As a critical apoptosis executioner, caspase-3 becomes activated and then enters into the nucleus to exert its function. However, the molecular mechanism of this nuclear entry of active caspase-3 ...

Immunohistochemistry was performed using monoclonal antibodies recognising cleaved caspase-3 (CC3), cleaved poly ... Danvers, MA, USA), anti-cleaved PARP antibody recognising Asp214 residue ...

In cell western (ICW) analysis was performed in parallel using anticleaved caspase-3 antibody to evaluate activation of apoptosis pathways in the same primary cultures treated with cisplatin. Results: ...