Here we report that in immature dendritic cells, the β1- and γ-subunits of AP-1 underwent caspase 3–catalyzed cleavage in their hinge regions, resulting in removal of the C-terminal 'ear' domains.

Sequential cleavage/activation of caspase cascades are key steps in triggering apoptosis. Activated caspases, such as caspase-3, target cytoplasmic and nuclear proteins involved in maintaining ...

Levels of caspase 3 activation were determined by quantifying positively staining tumour cells. Nasopharyngeal carcinoma-derived C15 and C17 tumour cells were used as control.