The immune system has evolved to act as a first responder against infections, and scientists have revealed how it knows when to activate.

An international study led by researchers at the University of Colorado Anschutz Medical Campus has identified a promising ...

Complement 3 glomerulopathy (C3G) and immunoglobulin A nephropathy (IgAN) are two rare types of kidney disease caused by underlying immune system activity.

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

Activation of the complement system kicks off a cascade of reactions that recruits immune cells to the site of an infection, flags pathogens for destruction, or even destroys microbes by poking ...

Recent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene transfer—activation of the complement system. A new article in ...

Overactive proteins in the immune system lead to these different conditions. C3G and IC-MPGN are rare kidney conditions. They occur when a part of the immune system, called the complement system ...

Complement responses may contribute to priming of the adaptive immune system or serious adverse ... The authors provide a comprehensive review of the complement cascade with a focus on ...