A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

cyclic AMP is synthesized from ATP by adenylyl cyclases (ACs), the activity of which is in turn controlled by the α-subunits (G αs and G αi) and βγ-subunits (G βγ) of stimulatory and ...

Adenylyl cyclase creates multiple cyclic AMP molecules, which fan out and activate protein kinases (PKA, in this example). Protein kinases can enter the nucleus and affect transcription.

Investigating conserved signaling pathways in different cell types shows that memory is not a unique property of neurons.

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight ...

The well-known second messenger cyclic adenosine 3′-5′-monophosphate (cAMP) plays a central role in the cells response to external stimuli. While the regulation of cAMP can be controlled by a ...

Lmo0052, renamed here PdeA, has homology to a cyclic di-AMP phosphodiesterase, GdpP (formerly YybT), of Bacillus subtilis and is able to degrade c-di-AMP to the linear dinucleotide pApA. Reduction of ...