The research compares how two bacterial species—Escherichia coli and Mycobacterium tuberculosis—use a signaling molecule called cyclic AMP (cAMP) to control important cellular functions.

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 ...

Being cut off in traffic, giving a presentation or missing a meal can all trigger a suite of physiological changes that allow the body to react swiftly to stress or starvation. Critical to this "fight ...

Woodward and Iavarone identified it as cyclic-di-AMP, a molecule discovered only two years ago in the bacteria Bacillus subitlis and thought to be involved in the production of spores.

Most recently, we funded Professor Ong's investigations into how to control the 'messenger molecule', cyclic AMP, which affects the rate at which cysts grow and expand in the kidneys.

Woodward and Iavarone identified it as cyclic-di-AMP, a molecule discovered only two years ago in the bacteria Bacillus subitlis and thought to be involved in the production of spores.

Normally, another molecule, phosphodiesterase, breaks down the cyclic AMP. However, Bibb and his colleagues discovered that phosphodiesterase did not do its job -- the wave of cyclic AMP did not ...

Most recently, we funded Professor Ong's investigations into how to control the 'messenger molecule', cyclic AMP, which affects the rate at which cysts grow and expand in the kidneys.

Synaptic actions of brain-derived neurotrophic factor (BDNF) are 'gated' by cyclic AMP (cAMP), but the underlying molecular mechanisms remain unclear. Here we report that cAMP regulates BDNF ...

Most recently, we funded Professor Ong's investigations into how to control the 'messenger molecule', cyclic AMP, which affects the rate at which cysts grow and expand in the kidneys.

More information: Faisa Omar et al. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases, Proceedings of the National Academy of Sciences (2019).