A new study published in Biochemistry sheds light on how bacteria regulate their genes, challenging long-held assumptions ...

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 ...

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences , 2019; 201822113 DOI: 10.1073/pnas.1822113116 Cite This Page : ...

May 27, 2010 New bacterial signaling molecule could lead to improved vaccines ...

Normally, another molecule, phosphodiesterase, breaks down the cyclic AMP. However, Bibb and his colleagues discovered that phosphodiesterase did not do its job -- the wave of cyclic AMP did not ...

Synaptic actions of brain-derived neurotrophic factor (BDNF) are 'gated' by cyclic AMP (cAMP), but the underlying molecular mechanisms remain unclear. Here we report that cAMP regulates BDNF ...

In ADPKD cells, cysts develop and grow because they express higher than normal levels of a 'messenger molecule' called cyclic AMP (or cAMP). One of the many known functions of cAMP is to tell ...

Scientists from the University of Sheffield are part of an international collaboration to develop a new class of drugs to treat a common genetic kidney disease which is a major cause of kidney ...

Scientists from the University of Sheffield are part of an international collaboration to develop a new class of drugs to treat a common genetic kidney disease which is a major cause of kidney ...