Inflammation and mitochondrial function as mechanisms in accelerated aging (AA) across substance use disorders (SUDs). This ...

Inflammation is the body’s response to injury and infection. To better understand how the body’s nerves and neurons detect ...

In contrast, biologics zero in on specific pathways that are ... Many biologics target cytokines that can trigger inflammation or are responsible for signaling that keeps it going.

Driven by growth factors and cytokines derived from the stem cell niche and surrounding immune cells, multiple signaling pathways tightly regulate ISC self-renewal and differentiation. Despite ...

In a healthy individual, T cells find cancer cells and release the protein interferon-gamma, a potent cytokine that stops ... fast-acting "innate" signaling pathways. Specifically, targeting ...

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...