DNA is often seen as the blueprint of life—carrying the code to govern the development and traits of an organism—but “there ...

In a study co-led by the University of Maryland School of Medicine (UMSOM), researchers have identified a “master regulator” gene, ZNFX1, that may act as a biomarker to help guide treatment in future ...

tried to improve RNA methylation activity of a bacterial non-site-specific DNA methyltransferase M.EcoGII with a residual activity for RNA methylation. The team then investigated its history using ...

Figure 1: Dnmt1 actively represses transcription using sequences that overlap the HRX repression domain. Figure 2: Dnmt1 686–812 represses transcription in a TSA-sensitive manner and has the ...

Another company looking to initiate clinical trials with an epigenetic-editor-based treatment for hepatitis is nChroma Bio.

The International Society of Stem Cell Research (ISSCR) is pleased to recognize Alice Rossi, PhD, Francis Crick Institute, UK ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

A study shows how manipulating epigenetic variation in wheat can reveal valuable heritable traits for crop improvement. By ...

and Medrano, J.* (2022) “Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors” J. Vis. Exp. 186, e62949. DOI: 10.3791/62949 Palfey, B ...

In a study co-led by the University of Maryland School of Medicine (UMSOM), researchers have identified a "master regulator" gene, ZNFX1, that may act as a biomarker to help guide treatment in future ...