New research shows that a single mutation in the DNA sequence for a methylation enzyme causes a cascade of faulty gene ...

tried to improve RNA methylation activity of a bacterial non-site-specific DNA methyltransferase M.EcoGII with a residual activity for RNA methylation. The team then investigated its history using ...

Her group found that 4mC appears only during sperm development, when methyltransferase genes switch on in a narrow developmental window and install 4mC specifically onto sperm DNA. What’s more ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

In addition, the study showed that two cancer drugs, DNA methyltransferase inhibitors (DNMTi) and PARP inhibitors, increase the expression of ZNFX1 and serve as a gateway to tumor suppressing ...

These include DNA methyltransferase and histone deacetylase (HDAC) inhibitors. Further candidates, including inhibitors of acetyl-lysine readers (bromodomain-containing proteins), are undergoing ...

and Medrano, J.* (2022) “Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors” J. Vis. Exp. 186, e62949. DOI: 10.3791/62949 Palfey, B ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...