This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have ...

"We were able to purify and reconstitute the central components that propel the eukaryotic replication fork, which for the first time enables us to study the process and its regulation by the cell ...

Scientists have deciphered molecular-level details of the complex choreography by which intricate cellular proteins recognize and bind to DNA to start the DNA replication process. The research may ...

For all species, the process of DNA replication requires the use of multiple different DNA polymerase enzymes.

How does the DNA replication process start? Scientists provide the first snapshot of how double-helix DNA begins to unwind and replicate.

That process starts at defined DNA sites, so-called origins of replication. To find these areas of the genome, cells use a protein machine called the origin recognition complex, or ORC.

Almost all life on earth is based on DNA being copied, or replicated, and understanding how this process works could lead to a wide range of discoveries in biology and medicine. Now for the first time ...

The DNA replication origin recognition complex (ORC) is a six-protein machine with a slightly twisted half-ring structure (yellow). ORC is proposed to wrap around and bend approximately 70 base ...