DNA replication is a complicated affair: Proteins must identify where on DNA to start replicating, unwind the double helix, synthesize a primer, and then elongate the DNA strand from the end of ...

Semiconservative replication was not the only model of DNA replication proposed during the mid-1950s, however. In fact, two other prominent hypotheses were put also forth: conservative replication ...

Terry L. Orr-Weaver et al. Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair. Current Biology , June 2015 DOI: 10.1016/j.cub.2015 ...

During DNA replication, a DNA lesion caused by stresses such as ultraviolet damage, oxidative damage, genotoxic drugs or growth medium deprivation may slown down or even arrest progression of the ...

DNA replication likes one direction. Not the boy band, but rather it prefers to replicate in a certain direction over the other. Publishing their findings in Science Advances, scientists have ...

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into ...

During cell division, the familiar double-stranded DNA helix gets split into two single strands, and the cell’s replication machinery moves along these single strands like a monorail, explains Allwein ...

Scientists reported a novel molecular mechanism for the regulation of PCNA cycling during DNA replication. They proved that ATAD5-RLC opens PCNA ring to be removed from DNA as a bona-fide PCNA ...

Liu: It's a really complicated topic. In really broad terms, replication stress is when the process of DNA replication — by which DNA is duplicated during the cell cycle — is slowed down or ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...