When patients are diagnosed with MS and have their first neurological symptoms, axonal loss has already occurred. 6 Because brain atrophy, specifically gray matter atrophy, creates permanent ...

Furthermore, there is a delay in VEPs by day 15 that is sustained at day 35 post EAE induction. Retinal thinning measured by OCT, on the other hand, is not apparent until day 35, consistent with ...

However, extensive loss of myelin generally leads to irreversible degeneration of the axon and cell body. In the demyelination process, areas of lipid degeneration in the myelin sheath are ...

Results: Autopsy revealed demyelination (with axonal loss) and neuronal damage in the cervical spinal cord and the distal part of the medulla oblongata. In the same region, ...

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nature Communications , 2023; 14 (1) DOI: 10.1038/s41467-023-42570-2 Cite This ...

To investigate the relationship between loss of myelin and axon degeneration, ... they found an inverse relationship of axon loss and demyelination when comparing the disease models.

Partial myelin loss slows transmission of visual information; severe myelin loss may stop the signal altogether. The researchers used IndCl to assess its impact on demyelinating visual pathway axons.

Monitoring Optic Nerve Lesion Length in Patients with Demyelinating Disease —For patients with acute optic neuritis, measuring early optic nerve lesion length may predict neuro-axonal loss and ...

Surprisingly and in contrast to the prevailing view, they found an inverse relationship of axon loss and demyelination when comparing the disease models.

If there is fairly significant axonal loss (decreased nerve conduction amplitude), the EMG should eventually yield increased insertion activity and increased amplitudes of motor units surveyed.

Selective deletion of AMPA receptors on oligodendrocytes prevents demyelination and axonal injury in autoimmune demyelination Activities. Study Groups; 2021 Annual Meeting; Departmental Seminars; ...