Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its ...

Nature Reviews Rheumatology - Targeting cathepsin K to prevent cartilage loss: evidence from a dog model of OA Skip to main content Thank you for visiting nature.com.

Articular cartilage is on the femur, the top of the tibia, and the back of the patella. It is a thin, shiny layer of cartilage. It acts as a shock absorber and helps bones move smoothly over one ...