Chemical structures called cyclopropanes can increase the potency of many drugs, but traditional methods to create this structure require highly reactive -- potentially explosive -- ingredients.

In a major advance for rational drug design, chemists have described several protein structures of a crucial player in cellular processes. The advance could bring new ideas for treatments of ...

Chirality: like a right hand and a left hand, two molecules can have the same composition, but a different shape and ...

Researchers discovered how to flip the structure of complex drug compounds using a simple reagent, offering a game-changing ...

Drug formulation, a critical step in drug development, involves determining a new drug's appropriate composition and chemical structure. AI algorithms can predict compounds' solubility and ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain ...

The opioid crisis, born out of governmental incompetence, has propelled two drugs, naltrexone and naloxone, into the forefront of American consciousness.It is important to know how each of these drugs ...

Salk scientists have discovered how a powerful class of HIV drugs binds to a key piece of HIV machinery. By solving, for the first time, three-dimensional structures of this complex while ...

Specifically, the work describes the C1 domain of protein kinase C, PKC, which helps regulate the protein’s activity in organisms. In the structures, the C1 domain wraps around different molecules of ...

In a major advance for rational drug design, a Texas A&M AgriLife team has described several protein structures of a crucial player in cellular processes. The advance could bring new ideas for ...