The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4.

Study reveals how variant forms of APOE protein impact risk of Alzheimer's disease ... suggesting that the different forms of the protein may affect whether and how toxic A-beta plaques form.

Carrying a particular version of the gene for apolipoprotein E (APOE) is the major known genetic risk factor for the sporadic, late-onset form of Alzheimer's disease, but exactly how that variant ...

Early studies found that different types, or variants, of the apoE gene — including apoE3 and apoE4 — influence one’s genetic risk for developing the disease. The apoE4 variant is the major genetic ...

These authors* showed (somewhat paradoxically) that one variant of the human APOE gene (APOE2) was associated with a propensity for tumor cells to metastasize, while a different variant (APOE4 ...

However, he was intrigued by the idea that different cell types might produce differentially lipidated particles. “The possibility that a microglia particle is different than an astrocyte particle is ...

Nixing astrocytic ApoE did not change the relative proportions of the different subsets of microglia in tau-ridden mice. That said, using immunohistochemistry of hippocampal sections, the researchers ...

BUFFALO, NY — June 12, 2025 — A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic ...

Cold exposure is shown to aggravate osteoarthritis (OA) by suppressing chondrocyte APOE, triggering lipid accumulation, ...