The apolipoprotein E (APOE) gene is a major genetic risk factor for Alzheimer's disease. There are three different versions of the APOE protein: APOE2, APOE3, and APOE4.

Because APOE was known to have modulatory effects on immune response, flow cytometric analysis of APOE gene variants in mice was performed and showed "enhanced recruitment of CD45+ leukocytes in ...

"This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition," says Eloise Hudry, PhD, of MGH-MIND ...

Cold exposure is shown to aggravate osteoarthritis (OA) by suppressing chondrocyte APOE, triggering lipid accumulation, ...

Early studies found that different types, or variants, of the apoE gene — including apoE3 and apoE4 — influence one’s genetic risk for developing the disease. The apoE4 variant is the major genetic ...

"This study has allowed us to sort out, in mice, which effects of the different types of APOE were most important to variation in amyloid plaque deposition," says Eloise Hudry, PhD, of MGH-MIND ...

Overall, the paper illustrates the striking degree of cross-talk between different cell types that steers the course of neurodegeneration. “If you modulate ApoE in astrocytes, it affects neurons, ...

There are many different types of coffee and coffee drinks available, and learning the difference can seem daunting, this different types of coffee guide will help you.

Other researchers at Keystone presented data on ApoE’s specific effects on different cell types. In particular, several groups investigated how different ApoE isoforms swayed gene expression in ...

Knowing about the different types of credit can help you understand your loan options and potentially even improve your credit score. Learn more about the various credit types.

Original Article Published: 20 July 2010 Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer ...