Alteration in the endoplasmic reticulum processing of cargo molecules by pathogens, or deficiencies in cargo handling by the endoplasmic reticulum machinery in a broad range of diseases including ...

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

Investigating how the unique structure of the ER arises and supports its function is critical to developing a mechanistic understanding of the many neurological diseases associated with ER ...

University of Western Australia research reveals how cells convert physical exercise forces into energy production responses.

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

The Golgi body (or Golgi complex, apparatus), and Endoplasmic reticulum (ER) are both organelles found in the majority of eukaryotic cells. They are very closely associated and show both ...

New long-term data show that patients with Fabry disease who are treated with migalastat (Galafold) experienced stable renal function after 2 years or more on the drug.

The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves as the site for the synthesis of various hormones.

The endoplasmic reticulum functions as a reservoir for calcium and carbohydrates and also serves as the site for the synthesis of various hormones. Cells adjust the expansion and networking of ...

The endoplasmic reticulum (green), plasma membrane (blue), mitochondria (pink), microtubules (tan), and ER-plasma membrane contacts (magenta) are segmented from FIB-SEM datasets of a Drosophila ...