Preeclampsia, a pregnancy-specific syndrome of hypertension and proteinuria, is characterized by defective placental vasculogenesis and widespread maternal endothelial dysfunction.

"By using assays to replicate the endothelial and vascular dysfunction that may be occurring in preeclampsia, we found metformin reduces endothelial dysfunction, improves vasodilation and is ...

Release of these toxins causes endothelial dysfunction and manifests as hypertension and multisystem organ injury. Currently, the only treatment for preeclampsia is delivery.

Their previous work has shown that outside of pregnancy, an infusion of leptin results in endothelial dysfunction. Belin de Chantemele’s lab has pioneered work showing that fat-derived leptin ...

The new research looking at the impact shows for the first time that the increase in leptin results in endothelial dysfunction in which blood vessels constrict, their ability to relax is impaired ...

In contrast, "the risk of nonischemic heart failure might be driven by other factors, such as the inflammatory profile, endothelial dysfunction, and cardiac remodeling induced by preeclampsia or ...

Placental dysfunction is an important part of the preeclampsia syndrome, which also involves systemic vasoconstriction, endothelial dysfunction, oxidative stress, activation of coagulation, and ...

Preeclampsia is a life-threatening pregnancy-associated vascular disorder characterized by new onset hypertension with proteinuria, and/or end organ dysfunction, and poses significant risks to ...