Esters are formed in condensation reactions and broken by hydrolysis. Fats and oils, important compounds in our diet, are naturally occurring esters and their structure explains their properties ...

Here we describe the structure of CETP at 2.2-Å resolution, revealing a 60-Å-long tunnel filled with two hydrophobic cholesteryl esters and plugged by an amphiphilic phosphatidylcholine at each end.