During fibrosis, fibroblasts — connective tissue cells that synthesize the extracellular matrix — “become somehow dysregulated, either by injury or by mutation,” he added. “These fibroblast cells ...

“In this paper, we develop a 3D connective tissue model that enables us to directly quantify how exposing cells in a 3D environment to different nutrients, growth factors or drug treatments results in ...

The findings suggest that connective tissue, and extracellular matrix proteins like lumican, operate outside of cells normally, but as disease or damage break down ECM, get sucked into and ...

Scientists have found a novel way that includes a new lab-grown material that could help slow and even reverse some of the ...

The composition of the extracellular matrix differs between tissue types. Though its main function is to provide an essential scaffold for cells, the extracellular matrix also regulates processes ...

Major components of the extracellular matrix (connective tissue) of the liver and the four most important targets of changes of the fibrotic matrix. The bindings of glycosaminoglycans ...

Fibroblasts are found in the connective tissue of our organs, where they ensure that the extracellular matrix is continuously renewed and remains healthy. If an injury occurs or tissue growth is ...

Most cases are caused by mutations in the genes encoding for the subunits composing type V collagen, an essential component of the extracellular matrix in many of the connective tissues in the body.

A new study reveals how collagen plays a crucial role in worsening Type 2 diabetes. While insulin and amylin hormones work ...

Collagen, which is considered as a key component for healthy skin may be worsening your type 2 diabetes. Read what the new study says about it.

While they are both proteins that work together in your connective tissue, ... Most of the arteries' elastin makes up the walls' extracellular matrix. However, as you age, this elastin degrades.

More information: Hyeonji Kim et al, Extracellular matrix-based sticky sealants for scar-free corneal tissue reconstruction, Biomaterials (2022). DOI: 10.1016/j.biomaterials.2022.121941 Journal ...