These extracellular vesicles were loaded with mRNA encoding interferon-gamma, an immune signaling protein. When the vesicles bind to receptors on tumor cells, they are internalized and release the ...

Extracellular vesicles (EV) are small membrane-bound structures that are secreted by various cell types, including tumor cells. Recent studies have shown that EVs are important for cell-to-cell ...

A recent review article highlights how extracellular vesicles (EVs) act as key players in the development of cancer drug resistance. The study explains how EVs, secreted by both cancerous and non ...

One reason glioblastoma is difficult to treat is that the downregulation of MHC-1, as well as other features of the tumor microenvironment, create an immunosuppressive environment that evades ...

Recent research published in Medcomm-Oncology reveals that extracellular vesicles (EVs) ... RNA, DNA, and other molecules between cancer cells and their microenvironment.

These small messengers could be a key to developing new cancer-fighting drugs and therapies, but it has been unclear how exactly the recipient cells absorb the extracellular vesicles and their cargo.

By blocking metabolism so effectively in cancer cells, JHU083 increases nutrient and oxygen availability in the tumor microenvironment and reduces extracellular acidification, all of which foster ...

The studies in mice confirmed that, when given as an injection to animals with breast cancer or melanoma, the treatment reduced tumor growth and improve survival, both at 20 day, and 35 day endpoints.

The findings are published in Science Advances in an article titled, “Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells.” ...

The cholesterol metabolite 27-hydroxycholesterol increases the secretion of extracellular vesicles which promote breast cancer progression. Endocrinology , 2021; DOI: 10.1210/endocr/bqab095 Cite ...