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ATP synthase can be thought of as a complex of two motors — the ATP-driven F1 motor and the proton-driven Fo motor — that rotate in opposite directions. The mechanisms by which rotation and ...
The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans ...
Citreoviridin, which is in the same class as aurovertin, targets the β subunit of the F1-ATP synthase, inhibits the growth and proliferation of BC cells as well as lung adenocarcinoma cells.
Reference: Sharma S, Luo M, Patel H, Mueller DM, Liao M. Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1–Fo coupling. Nat Struct Mol Biol .
Mechanistically, these muropeptides were shown to enter intestinal-cell mitochondria to interact with the F1 complex of ATP synthase, stabilizing the complex and increasing mitochondrial respiration.