Now, scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying cell processes that depend on this signaling.

Cell surface receptors belonging to the family of G protein coupled receptors (GPCRs) – also known as seven-transmembrane, heptahelical or serpentine, receptors – are involved in the ...

The G protein biosensors constitute a GoLogo motif domain of Rap1GAP (interacts with all Gα i/o/z subunits), a regulator of G protein signaling (RGS) domain of p63RhoGEF (interacts with Gα q/11 ...

Oct. 26, 2022 — Researchers have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs.

G-protein-coupled receptors (GPCRs) remain major drug targets, despite an incomplete understanding of how they signal through 16 non-visual G-protein signal transducers (collectively named the ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

More information: Lijie Liu et al, Redox regulation of G protein oligomerization and signaling by the glutaredoxin WG1 controls grain size in rice, The EMBO Journal (2025). DOI: 10.1038/s44318-025 ...

O'Neill PR, Karunarathne WK, Kalyanaraman V, Silvius JR, Gautam N. G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular ...