Scientists have few good methods for manipulating and investigating G-protein signaling. Now, scientists have developed small proteins to selectively block a certain type of G-protein signaling ...

Heterotrimeric G proteins, consisting of α, β, and γ-subunits provide the signal coupling mechanisms to this superfamily of receptors.

SKNY-1 was previously shown to achieve up to 30% weight loss, reverse nicotine craving, and preserve muscle mass in an animal model-and is designed to avoid the CNS side effects that halted earlier CB ...

More information: Lijie Liu et al, Redox regulation of G protein oligomerization and signaling by the glutaredoxin WG1 controls grain size in rice, The EMBO Journal (2025).

Classically, GPCR-mediated signal transduction was thought to occur via linear signaling pathways, with a given GPCR selectively engaging a single heterotrimeric G protein family defined by the ...

The ascidian Ciona, a genus of sea squirts, undergoes metamorphosis from active, tadpole-like larvae to sessile adults.

Researchers uncovered the role of the third intracellular loop in the G protein-coupled receptors' signaling mechanism, which could lead to a more targeted approach to drug discovery and a ...

Regulator of G protein signaling (RGS) proteins control signal termination by serving as GTPase accelerating proteins (GAPS); i.e., they increase the rate of GTP hydrolysis by Gα.

G proteins: Intracellular signaling molecules. Gs, Gq and Gi are among the known types of G proteins. Cell excitation: It is known that β cells, nerve cells and muscle cells are electrically ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...