GABA A receptors are a family of pentameric chloride ion channels composed of combinations of any of 19 types of subunits. The most common combination is two α subunits, two β subunits, and one ...

The potential therapeutic target of brain GABA type A deficiency linked to reduced receptors is undercut by an imaging study showing no reduction in receptors, although possible impairment in ...

Original Article Published: 07 December 2016 GABAb Receptor Mediates Opposing Adaptations of GABA Release From Two Types of Prefrontal Interneurons After Observational Fear Lei Liu, Wataru Ito ...

A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA release into the extracellular space during intense network ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor ...

GABA Receptor Antagonist - Pipeline Insight, 2019 offers comprehensive insights of the pipeline (under development) therapeutics scenario and growth prospects across GABA Receptor Antagonist ...

Myotonic dystrophy: GABA receptors implicated in sleepiness, via mouse model Date: September 29, 2022 Source: Emory Health Sciences Summary: People with the inherited disorder myotonic dystrophy ...

Overexpression of either of two GABA receptor types compensated for the loss of the other, suggesting that these two receptors can function in a similar way in the SCN, even though they have been ...

However, there has been no strong link between GABA and type 2 diabetes until recently when it was shown that GABA is important for maintaining and potentially also in the making of new beta cells.

Because of their GABA receptor sub-type specificity, the compounds have a greatly reduced liability to produce sedation, motor incoordination, memory impairments and tolerance, side effects ...

"All of these drugs target GABA-A receptors, and we had some clues that these receptors might be affected in DM, because of years of reports on post-operative anesthesia complications," says ...

A patent on the use of GABA-A receptor antagonists for myotonic dystrophy is held by Bassell and Wang, so they could potentially benefit from future commercialization.