Here, we reveal a novel, Gsk3b-independent function of Frat converging on the activation of JNK and AP-1. Both these have been used as readouts for the noncanonical Frizzled/PCP pathway, ...

Study participants with genetic variants in GSK3B all presented with similar symptoms, including developmental delay, autism, sleeping disturbances and other behavioral challenges.

An international study links GSK3B gene variants to autism and developmental delays. By analyzing 15 cases and using mouse models, researchers showed disrupted development in excitatory neurons.

These are two marine molecules, meridianine and lignarenone B, able to alter the activity of GSK3B activity, a protein associated with several neurodegenerative diseases. Advanced Search.

GSK3B has always been an appreciated molecule in the treatment for Alzheimer's disease. However, clinical trials with all potential inhibitors caused adverse effects, which were a disappointment.

By inhibiting GSK3B in mice, investigators observed that expected development was disrupted and led to a neurodevelopmental disorder with similar features to autism. The findings will add to existing ...