Alexa, Make Me a Protein: Denovium’s AI Reimagines De Novo Proteins December 22, 2020. By Alex ... “I want X, Y, and Z, give me the end of the protein sequence.” ...

There are many mutations you can make to your protein: from point mutations, to truncations, to complex combinations of protein domains connected by linkers. Too many mutations too quickly can give ...

Protein sequencing refers to methods for determining the amino acid sequence of proteins (or peptides) and analysis of the sequence, for example to infer protein conformation. Techniques include ...

Of those 180 million protein sequences, scientists have so far worked out the structure of just 180,000 proteins. DeepMind’s new database provides predictions for more than double the number of ...

Different variants on the same protein, or proteoforms, can arise because of RNA splicing, posttranslational sequence changes like protein cleavage, or covalent modifications like phosphorylation.

A major scientific advance in protein modeling developed by Microsoft Research AI for Science, has been published in Science.

Research team used ProteinMPNN to expand the sequence space of synthetic binding proteins (SBPs), improving their solubility and stability, and showed ProteinMPNN-designed proteins outperform ...

The team experimentally quantified the aggregation of more than 100,000 protein sequences, and used this dataset to train the new AI tool for predicting aggregation from sequence.

(a) Evolutionary pressure (left) to maintain favorable interactions between physically interacting amino acid residues (red circles) in the three-dimensional fold of a protein (curved line) leaves ...

There are 210 thousand experimentally determined protein structures but 250 million known protein sequences. ... "Each provides unique details, but together they give a fuller, ...