Medically reviewed by Lindsay Cook, PharmD Irritable bowel syndrome with constipation (IBS-C) is characterized by symptoms ...

Mononuclear cells express enzymes involved in the NO/cyclic guanosine monophosphate (cGMP) generating system, as well as PDE5. The objective of the study was to determine the effect of sildenafil ...

The CNP-bound receptor activates a molecule, cyclic guanosine monophosphate (cGMP), which in turn activates protein kinase G (PKG) that phosphorylates a membrane ion channel. This ion channel is ...