A discovery with major implications for cancer treatment has been made by a team of researchers from Rensselaer Polytechnic ...

I was recently talking to a very well-educated pancreatic cancer patient about therapies that are seemingly useful in treating the dreadful cancer. The subject of Sonic Hedgehog pathway inhibitor ...

Hedgehog signaling pathway for breast cancer identified Date: November 13, 2014 Source: University of Texas M. D. Anderson Cancer Center Summary: Molecules called long non-coding RNAs (lncRNAs ...

Zinc deficiency linked to activation of Hedgehog signaling pathway Date: April 16, 2015 Source: Rensselaer Polytechnic Institute Summary: Zinc deficiency -- long associated with numerous diseases ...

The Hedgehog Signaling Pathway Database, through the San Francisco State University, provides a number of online tools for researchers studying this pathway.

Furthermore, several Hedgehog signaling pathway inhibitors, such as vismodegib and sonidegib, have been developed for cancer treatment, targeting specific molecules involved in Hedgehog signaling ...

GDC-0449 targets the Smoothened (SMO) protein in the Hedgehog signaling pathway. It was approved for use in basal cell carcinoma and is marketed as vismodegib.

Proteins use the hedgehog signaling pathway to stimulate cells to grow and spread, so it's particularly active while humans (and all mammals) are developing in the womb.

The hedgehog signaling pathway helps regenerate damaged tissue in the airways and pancreas. Activating it may protect tissue against smoke inhalation and prevent diabetes progression.