The second Hexagon Piece is hidden in the Fish Farm, so it's most convenient to grab it in chapter three when you're going there to find boat fuel. It's towards the far end near the shack with the ...

Where to find the Hexagon Pieces On your way to the Fish Farm in chapter 3 of Capcom's Resident Evil 4 remake, you'll come across a dais with three conspicuous, hexagonal gaps.