Insulin signaling suppressed by decoys Date: February 25, 2020 Source: Scripps Research Institute Summary: The discovery of an insulin 'decoy' molecule shakes up understanding of insulin signaling ...

Recent advances in glucose management are reshaping our understanding of cognitive decline and dementia prevention. Energy ...

Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from ...

“In the nematode C. elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides. Here, we describe a novel, non-signaling isoform of the ...

It describes a new player in the insulin signaling system, one that may offer insights into insulin resistance, a feature of type 2 diabetes. The scientists are now assessing whether a similar ...

Insulin signaling is altered in the pancreas, a new study shows for the first time in humans. The errant signals disrupt both the number and quality of beta cells -- the cells that produce insulin.

This research finds that Insulin resistance in the general population seems likely to be caused by a series of cell-specific signaling defects some of which appear to be sex-specific. In addition ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck ...

Protein tyrosine phosphatase receptor type J (PTPRJ) is a negative regulator of insulin signaling in neuronal cells, according to a new study, and appears to have a role in nervous system development.

IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

Brain Insulin in Worms and Flies: Biology Expanded. By 1997, molecules and signaling pathways homologous to the CNS insulin signaling system in mammals had been discovered in two very simple ...